I try to apply a monolithic myself. So, bigger policies are set, but there are fewer GPOS, but it really all depends.
So, like all security GPOs, apps GPOs, Windows tuning GPO, and so on.
But to answer your question, I would say yes. Often, I see WEM apply all the GPOs, but the timing is off, and it will miss some, but it's doing async mode, and it will apply them, but a couple might be missing. Then the next time it gets them 100%.
Often at times, I use this to get around that.
Agent | Workspace Environment Management 2402 (citrix.com)
SyncForegroundPolicy. Lets you configure the SyncForegroundPolicy registry value during agent installation. This policy setting determines whether Group Policy processing is synchronous. Accepted values: 0, 1. If the value is not set or you set the value to 0, Citrix WEM Agent User Logon Service does not delay logons, and user Group Policy settings are processed in the background. If you set the value to 1, Citrix WEM Agent User Logon Service delays logons until the processing of user Group Policy settings completes. By default, the value does not change during installation.
s://docs.citrix.com/en-us/workspace-environment-management/current-release/install-and-configure/agent-host.html#system-settings