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Connection refused from Windows client machines

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I setup SSL binding according to the following - https://support.citrix.com/article/CTX205253 


The issue is that all my servers clients has no issues and everything is working, but with my Windows 10 clients I am getting the error - 


 The connection to 'xxxxxxxx' failed. <br />Error: ConnectionRefused (0x274d). <br />System.Net.Sockets.SocketException No connection could be made because the target machine actively refused it mu virtual server IP address:443                                                                                                                                                                                                                                                                                     



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