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Not able to open any citrix application from any browser

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Hello Team,  


In Our Org. we are running Citrix 6.5.0 Version on the server 2008 R2 Enterprises and we are facing some weird issue  while accessing any application from Citrix App 

Ex. Like  client machine have Chrome or Firefox so some time it runs through Chrome but some time fails 

It gives attached error even though the file and permission are perfect and exist on server 


So anyone provides some guidance or share the expert adivse will help us to sort out the issue  




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